Wednesday, 23rd September 2020 - 8:18 am

Dr. R. Krishna

Associate Professor

Centre for Bioinformatics

About
Research Area

I am basically structural biologist and working on the structures of proteins, protein-protein interactions and protein-ligand interactions to understand the macromolecules thoroughly at the atomic level through computation and X-Crystallography. Our lab is working on proteins involved in cancers and tuberculosis. I have completed my MSc, Mphil and Ph.D in the department of crystallography and Biophysics, University of Madras. I have joined as research associate at Prof. M. Vijayan’s Lab , Molecular Biophysics Unit, Indian Institute of science, Bangalore. There I got trained in macromolecular crystallography.

 

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Publications

Notable Publications

Krishna R, Manjunath GP, Kumar P, Surolia A, Chandra NR, Muniyappa K, Vijayan M. Crystallographic identification of an ordered C-terminal domain and a second nucleotide-binding site in RecA: new insights into allostery, Nucl.Acids Res. 34: 2186-2195, 2006 [IF:10.162]

Krishna R, Prabu JR, Manjunath GP, Datta S, Chandra NR, Muniyappa K, Vijayan M, Snapshots of RecA Protein Involving Movement of the C-domain and Different Conformations of the DNA-binding Loops: Crystallographic and Comparative Analysis of 11 Structures of Mycobacterium smegmatis RecA, J.Mol.Biol 367, 1130-1144, 2007 [I.F: 4.632]

Wei Liang, Shuyu Miao, Bo Zhang, Shaohua He, Chengchao Shou, Panneer S. Manivel, Ramadas Krishna, Yiding Chen, Yuenian Eric Shi, Synuclein gamma protects Akt and mTOR and renders tumor resistance to Hsp90 disruption. Nature Oncogene (2014), 1-8 [I.F: 7.51]

Kannan Muthu, Manivel Panneerselvam, Nishith Saurav Topno, Manikandan Jayaraman, Krishna Ramadas, Structural perspective of ARHI mediated inhibition of STAT3 signaling: An insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ, Cellualar Signalling (2015), 27, 739-755 [I.F:3.93]

Kumar, A., Thotakura, P. L., Tiwary, B. K., & Krishna, R. (2016). Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen protein-protein interactions. BMC microbiology, 16(1), 1. 84 [I.F:2.64]

Awards & Achievements​

UGC-RESEARCH AWARD

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